Phenotypes Associated with This Genotype

Genotype
MGI:4410505

• Allelic Composition: Wls^{Gt(RRJ545)Byg}/Wls^{Gt(RRJ545)Byg}
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:154679 )

• mice die prior to E10.5

embryo

abnormal developmental patterning ( J:154679 )

• development of the body axis is impaired unlike in wild-type mice

abnormal germ layer development ( J:154679 )

• from E6.5 to E8.5, mice remain as egg cylinders with only two layers of tissue unlike wild-type mice

abnormal ectoderm development ( J:154679 )

• the ectodermal layer is abnormally thick and grows to become irregular and folded unlike in wild-type mice

• the anterior ectoderm fails to develop unlike in wild-type mice

abnormal endoderm development ( J:154679 )

• mice lack definitive endoderm unlike wild-type mice

absent mesoderm ( J:154679 )

failure of primitive streak formation ( J:154679 )