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Phenotypes Associated with This Genotype
Genotype
MGI:4410314
Allelic
Composition
Efemp2tm1.1Tynk/Efemp2tm1.1Tynk
Tg(Tagln-cre)1Her/0
Genetic
Background
involves: C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Efemp2tm1.1Tynk mutation (0 available); any Efemp2 mutation (26 available)
Tg(Tagln-cre)1Her mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• at P14, the elastic laminae is disrupted unlike in wild-type mice
• at 12 weeks, aorta are less distensible than in wild-type mice
• the elastic laminae is thicker and spongy with aberrant deposits in the interlaminar spaces unlike in wild-type mice
• at 12 weeks, aorta are less distensible and stiffer than in wild-type mice


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
01/20/2026
MGI 6.24
The Jackson Laboratory