Phenotypes Associated with This Genotype

Genotype
MGI:4410313

• Allelic Composition: Efemp2^tm1.2Tynk/Efemp2^tm1.2Tynk
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:154659 )

• mice die shortly after birth

cardiovascular system

abnormal aorta morphology ( J:154659 )

• the aorta is tortuous unlike in wild-type mice

abnormal aorta elastic tissue morphology ( J:154659 )

• the aortic elastic laminae is complete disarranged

• the elastogenesis is abolished

muscle

diaphragmatic hernia ( J:154659 )

• severe at birth