Phenotypes Associated with This Genotype

Genotype
MGI:4399750

• Allelic Composition: Gt(ROSA)26Sor^tm1(DTA)Jpmb/Gt(ROSA)26Sor⁺; Tg(Slc16a8-cre/ERT2,-EGFP)1Moss/0
• Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

vision/eye phenotype ( J:154671 )

N • despite loss of retinal pigment epithelia in tamoxifen treated mice, the retinal pigment epithelial barrier function is maintained and retinal vasculature is normal

abnormal retina pigment epithelium morphology ( J:154671 )

• loss of retinal pigment epithelium in tamoxifen treated mice is compensated by increased size of neighboring cells without loss of cell thickness preventing gaps in the epithelium

retina pigment epithelium atrophy ( J:154671 )

• 6 days after tamoxifen treatment, retinal pigment cells become round and are exuded from the retina

• 2 weeks after tamoxifen treatment, retinal pigment cells are enlarged and irregularly shaped with clumps of extruding cells

• 14 days after tamoxifen treatment the retinal pigment cells are reduced 68% compared to in mice lacking the cre transgene

• however, loss of retinal pigment cells is stabilized between day 14 and 6 months

retina fold ( J:154671 )

• following tamoxifen treatment, mice develop variable retinal folds termed rossetting unlike wild-type mice

abnormal rod electrophysiology ( J:154671 )

• under scotopic conditions at 6 weeks and 6 months, tamoxifen-treated mice exhibit decreased a and b wave amplitudes compared with wild-type mice

pigmentation

abnormal retina pigment epithelium morphology ( J:154671 )

• loss of retinal pigment epithelium in tamoxifen treated mice is compensated by increased size of neighboring cells without loss of cell thickness preventing gaps in the epithelium

retina pigment epithelium atrophy ( J:154671 )

• 6 days after tamoxifen treatment, retinal pigment cells become round and are exuded from the retina

• 2 weeks after tamoxifen treatment, retinal pigment cells are enlarged and irregularly shaped with clumps of extruding cells

• 14 days after tamoxifen treatment the retinal pigment cells are reduced 68% compared to in mice lacking the cre transgene

• however, loss of retinal pigment cells is stabilized between day 14 and 6 months