Phenotypes Associated with This Genotype

Genotype
MGI:4399728

• Allelic Composition: Tg(Cnp-Gpr17)1Qrlu/0
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality ( J:154602 )

• the majority of mice die around 3 weeks of age with a few surviving into adulthood

nervous system

nervous system phenotype ( J:154602 )

N • despite loss of mature oligodendrocytes, mice exhibit no abnormal neuronal cell death or axonal loss

seizures ( J:154602 )

• starting at 2 weeks

abnormal oligodendrocyte morphology ( J:154602 )

• oligodendrocytes are deficient in myelination compared to in wild-type mice

• oligodendrocyte maturation is inhibited compared to in wild-type mice

gliosis ( J:154602 )

• in the spinal cord at P20

microgliosis ( J:154602 )

• in the brain at P20

abnormal myelination ( J:154602 )

• oligodendrocytes are deficient in myelination compared to in wild-type mice

• at P14, few myelinated axons are detected in the optic nerve unlike in wild-type mice

• at P21, hardly any myelinated axons are detected in the optic nerve unlike in wild-type mice

behavior/neurological

tremors ( J:154602 )

• starting at 2 weeks and worsening by week 3

hindlimb paralysis ( J:154602 )

• starting at 2 weeks

seizures ( J:154602 )

• starting at 2 weeks

immune system

microgliosis ( J:154602 )

• in the brain at P20

hematopoietic system

microgliosis ( J:154602 )

• in the brain at P20