Phenotypes Associated with This Genotype

Genotype
MGI:4399726

• Allelic Composition: Cpox^nct/Cpox^nct
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

abnormal lens morphology ( J:6014 , J:5481 )

• there is a decrease in crystallin and leakage of crystallin from the lens (J:6014)

• histological analysis shows slower than normal loss of lens cell nuclei, especially in the bow area, by 7 days of age (J:5481)

• persistence of cell nuclei in the bow area is noteable at 12-13 days of age (J:5481)

abnormal lens fiber morphology ( J:5481 )

• distal portions of many fibers swell and become hydropic

• at 20-23 days of age lens fibers are disintegrating posterior to the center of the lens with histology showing broken cell borders, many vacuoles and large swollen cells

hydropic eye lens fibers ( J:5481 )

cataract ( J:5481 )

• an opaque spot first appears in mutant mice between 16 to 22 days of age

• the whole lens is opaque by 4-5 weeks of age