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Phenotypes Associated with This Genotype
Genotype
MGI:4399127
Allelic
Composition
Zap70tm2.1Weis/Zap70tm2.1Weis
Genetic
Background
B6.129S4-Zap70tm2.1Weis
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zap70tm2.1Weis mutation (1 available); any Zap70 mutation (55 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• significant decrease in the relative percentage and absolute number of CD4 and CD8 single positive subsets
• however, total thymic cellularity is only mildly decreased
• the majority of CD8+ thymocytes are at the immature intermediate stage
• the relative percentages and absolute numbers of the CD4 single positive subsets in the thymus as well as in the periphery are substantially decreased
• the relative percentages and absolute numbers of the CD8 single positive subsets in the thymus as well as in the periphery are substantially decreased

hematopoietic system
• significant decrease in the relative percentage and absolute number of CD4 and CD8 single positive subsets
• however, total thymic cellularity is only mildly decreased
• the majority of CD8+ thymocytes are at the immature intermediate stage
• the relative percentages and absolute numbers of the CD4 single positive subsets in the thymus as well as in the periphery are substantially decreased
• the relative percentages and absolute numbers of the CD8 single positive subsets in the thymus as well as in the periphery are substantially decreased

endocrine/exocrine glands
• significant decrease in the relative percentage and absolute number of CD4 and CD8 single positive subsets
• however, total thymic cellularity is only mildly decreased


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/07/2024
MGI 6.23
The Jackson Laboratory