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Phenotypes Associated with This Genotype
Genotype
MGI:4398918
Allelic
Composition
Acvrl1tm2Spo/Acvrl1tm2Spo
Tg(Acvrl1-cre)L1Spo/0
Genetic
Background
involves: 129 * 129S4/SvJae * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Acvrl1tm2Spo mutation (0 available); any Acvrl1 mutation (1 available)
Tg(Acvrl1-cre)L1Spo mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

cardiovascular system
• the vascular smooth muscle cell layers of the dorsal aorta are more compact than in wild-type mice
• lung vasculature are dilated, tortuous, and irregular unlike in wild-type mice
• lung blood vessels exhibit thinning and irregular vascular smooth muscle cell layers compared to in wild-type mice
• from E15.5 to E17.5, yolk sac blood vessels bulge and are larger than the umbilical vessels unlike in wild-type mice
• extraembryonic vessels exhibit increased lumen diameter and decreased wall thickness compared to in wild-type vessels
• vitelline vessels are dilated, convoluted, tortuous, and also make abnormal direct connections between arteries and veins without connecting capillary beds unlike wild-type vessels
• the vascular smooth muscle cell layers of the pulmonary vessels, vitelline vessels, and the dorsal aorta are more compact than in wild-type mice
• vitelline vessels are dilated, convoluted, tortuous, and also make abnormal direct connections between arteries and veins without connecting capillary beds unlike wild-type vessels
• pulmonary and vitelline vessels

embryo
• from E15.5 to E17.5, yolk sac blood vessels bulge and are larger than the umbilical vessels unlike in wild-type mice
• extraembryonic vessels exhibit increased lumen diameter and decreased wall thickness compared to in wild-type vessels
• vitelline vessels are dilated, convoluted, tortuous, and also make abnormal direct connections between arteries and veins without connecting capillary beds unlike wild-type vessels

respiratory system
• lung vasculature are dilated, tortuous, and irregular unlike in wild-type mice
• lung blood vessels exhibit thinning and irregular vascular smooth muscle cell layers compared to in wild-type mice

muscle
• the vascular smooth muscle cell layers of the pulmonary vessels, vitelline vessels, and the dorsal aorta are more compact than in wild-type mice


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/16/2021
MGI 6.16
The Jackson Laboratory