Phenotypes Associated with This Genotype

Genotype
MGI:4398747

• Allelic Composition: Os/Os
• Genetic Background: involves: 101 * C3H

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality between implantation and placentation, complete penetrance ( J:5017 )

embryo

embryonic growth arrest ( J:5017 , J:5768 )

• cells of the developing embryo appear abnormal between the 7th and 8th division with suggestion of mitotic dysfunction (J:5017)

• the most striking abnormalities are seen by the middle of the 4th day when many embryonic cells contain fragmented, pycnotic chromatin and lack nuclear membrane and nucleolus (J:5017)

• in culture, blastocysts show rapid degeneration of the inner cell mass compared with control embryos (J:5768)

decreased embryo size ( J:5768 )

• noted as early as E4.5

cellular

abnormal mitosis ( J:5768 )

increased mitotic index ( J:5768 )

• E4.5 embryos have an index nine times that of controls

• more than one third of cells contain mitotic figures

growth/size/body

decreased embryo size ( J:5768 )

• noted as early as E4.5