Phenotypes Associated with This Genotype

Genotype
MGI:4398698

• Allelic Composition: Efna3^tm1.1Ebp/Efna3^tm1.1Ebp
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal excitatory postsynaptic potential ( J:154648 )

• following the end of the first train of theta burst stimulation, field excitatory postsynaptic potential is reduced compared to in wild-type mice

abnormal glutamate-mediated receptor currents ( J:154648 )

• following a single pulse release of glutamate from presynaptic terminals or theta burst stimulation, glutamate transporter current is increased compared to in wild-type mice

reduced long-term potentiation ( J:154648 )

• after stimulation with theta bursts, mice exhibit strong reduction in long term potentiation compared with wild-type mice

• however, long term potentiation following theta burst stimulation came be rescued by treatment with (2S, 3S)-3-{3-[4-(trifluoromethyl)benzoylamino)benzyloxy}aspartate (TFB-TBOA) and long term potentiation following tetanic stimulation is normal