Phenotypes Associated with This Genotype

Genotype
MGI:4367908

• Allelic Composition: Del(17Abcg1-Cbs)2Yah/+
• Genetic Background: B6.129P2-Del(17Abcg1-Cbs)2Yah

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased circulating homocysteine level ( J:154298 )

• homocysteine levels are increased compared to in wild-type mice

behavior/neurological

behavior/neurological phenotype ( J:214512 )

N • normal rotarod test results

N • object recognition and Morris water maze tests normal

enhanced contextual conditioning behavior ( J:214512 )

• freezing times in response to adverse stimuli are increased over controls

decreased locomotor activity ( J:214512 )

• poorer treadmill performance over time but locomotion is normal

abnormal social investigation ( J:214512 )

• lower interaction with a second test mouse after normal interaction with the first test subject

nervous system

enhanced long-term potentiation ( J:214512 )

• longer LTP response than for controls using a high frequency stimulation protocol