Phenotypes Associated with This Genotype

Genotype
MGI:4367769

• Allelic Composition: Kdr^tm1.1Jamb/Kdr^tm1.1Jamb
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased susceptibility to injury ( J:154336 )

• following intracorneal administration of a cre coding plasmid, mice exhibit an 161% increase in lymphangiogenesis but not hemangiogenesis in response to suture injury compared with mice injected with the empty vector

• mice treated intracorneally with a cre coding plasmid fail to exhibit a decrease in lymphangiogenesis when expression of soluble Kdr unlike similarly treated wild-type mice

immune system

abnormal lymphangiogenesis ( J:154336 )

• following intracorneal administration of a cre coding plasmid, mice exhibit an 161% increase in lymphangiogenesis but not hemangiogenesis in response to suture injury compared with mice injected with the empty vector

• mice treated intracorneally with a cre coding plasmid fail to exhibit a decrease in lymphangiogenesis when expression of soluble Kdr unlike similarly treated wild-type mice

lymphatic vessel hyperplasia ( J:154336 )

• following intracorneal administration of a cre coding plasmid, mice exhibit an 161% increase in lymphangiogenesis but not hemangiogenesis in response to suture injury compared with mice injected with the empty vector

• mice treated intracorneally with a cre coding plasmid fail to exhibit a decrease in lymphangiogenesis when expression of soluble Kdr unlike similarly treated wild-type mice