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Phenotypes Associated with This Genotype
Genotype
MGI:4367768
Allelic
Composition
Kdrtm1.1Jamb/Kdrtm1.1Jamb
Tg(Pax6-cre,GFP)1Pgr/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * FVB/N * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kdrtm1.1Jamb mutation (0 available); any Kdr mutation (71 available)
Tg(Pax6-cre,GFP)1Pgr mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• at P0, corneas are densely covered with lymphatic vessels unlike in wild-type mice
• however, mice exhibit normal limbal blood vessels and corneal hemangiogenesis in response to suture injury

immune system
• hyperplastic lymphatic vessels in the cornea lack erythocytes, do not have a continuous basement membrane, and containing partly overlapping thin endothelial cells free of pericyte coverage unlike wild-type lymphatic vessels
• at P0, corneas are densely covered with lymphatic vessels unlike in wild-type mice

cellular
• hyperplastic lymphatic vessels in the cornea do not have a continuous basement membrane unlike wild-type lymphatic vessels


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/16/2024
MGI 6.23
The Jackson Laboratory