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Phenotypes Associated with This Genotype
Genotype
MGI:4367614
Allelic
Composition
Apoetm1Unc/Apoetm1Unc
Mmp9tm1Tvu/Mmp9tm1Tvu
Genetic
Background
involves: 129P2/OlaHsd * 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoetm1Unc mutation (34 available); any Apoe mutation (163 available)
Mmp9tm1Tvu mutation (2 available); any Mmp9 mutation (48 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• following temporary ligation, mice develop intimal atherosclerotic plaques with reduced volume, length, smooth muscle cells, and intraplaque foam cells and macrophages compared with similarly treated Apoetm1Unc homozygotes
• following temporary ligation, fewer smooth muscle cells are found in atherosclerotic plaques compared to in similarly treated Apoetm1Unc homozygotes

immune system
• following temporary ligation, fewer foam cells and macrophages are found in atherosclerotic plaques compared to in similarly treated Apoetm1Unc homozygotes

muscle
• following temporary ligation, fewer smooth muscle cells are found in atherosclerotic plaques compared to in similarly treated Apoetm1Unc homozygotes

hematopoietic system
• following temporary ligation, fewer foam cells and macrophages are found in atherosclerotic plaques compared to in similarly treated Apoetm1Unc homozygotes


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/18/2025
MGI 6.24
The Jackson Laboratory