Phenotypes Associated with This Genotype

Genotype
MGI:4367467

• Allelic Composition: Apoe^tm1Unc/Apoe^tm1Unc; Nos3^tm1Plh/Nos3^tm1Plh
• Genetic Background: B6.129-Nos3^tm1Plh Apoe^tm1Unc

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

increased susceptibility to atherosclerosis ( J:103306 )

• increase in lesion area relative to Apoe single mutants when fed a Western type diet

• unlike in Apoe single mutants no difference in lesion area is seen at 4 months of age in double mutants fed a Western type diet

• all mice show distal coronary arteriosclerosis associated with perivascular and endomyocardial fibrosis and endomyocardial scars consistent with nontransmural infarction

aortic dissection ( J:103306 )

• 2 of 12 mice fed a Western type diet for 16 weeks developed acute Stanford type B aortic dissections that are not seen in Apoe single mutants

thick interventricular septum ( J:103306 )

• thickening of the interventricular septum is seen in double mutants fed a Western type diet for 16 weeks

increased heart left ventricle posterior wall thickness ( J:103306 )

• thickening of the LV posterior wall is seen in double mutants fed a Western type diet for 16 weeks

dilated heart left ventricle ( J:103306 )

• 2 of 10 mice fed a Western type diet for 16 weeks displayed massive dilation of the left ventricle

cardiac fibrosis ( J:103306 )

• all mice show distal coronary arteriosclerosis associated with perivascular and endomyocardial fibrosis and endomyocardial scars consistent with nontransmural infarction

increased susceptibility to induced aneurysm formation ( J:103306 )

• 3 of 12 mice fed a Western type diet for 16 weeks developed atherosclerotic suprarenal abdominal aortic aneurysms that are not seen in Apoe single mutants

decreased cardiac muscle contractility ( J:103306 )

• decrease in fractional shortening in double mutants fed a Western type diet for 16 weeks

increased mean systemic arterial blood pressure ( J:103306 )

• increased relative to wild-type controls and Apoe single mutants but similar to Nos3 single mutants

muscle

decreased cardiac muscle contractility ( J:103306 )

• decrease in fractional shortening in double mutants fed a Western type diet for 16 weeks