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Phenotypes Associated with This Genotype
Genotype
MGI:4367214
Allelic
Composition
Nos1tm1Plh/Nos1tm1Plh
Nos3tm1Plh/Nos3tm1Plh
Genetic
Background
involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nos1tm1Plh mutation (3 available); any Nos1 mutation (10 available)
Nos3tm1Plh mutation (1 available); any Nos3 mutation (9 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• survival at 20 months is reduced compared to Nos3 or Nos1 single mutant mice
• survival at 20 months is reduced compared to Nos3 or Nos1 single mutant mice
• the relative risk of death by 20 months of age is increased 7.3 fold compared to Nos3 single mutants and 3.0 fold compared to Nos1 single mutants
• mortality is increased in males compared to females

cardiovascular system
• develop age related concentric remodeling with marked increase in relative wall thickness
• increase in wall thickness and decrease in systolic and diastolic dimensions with age
• attenuation of the beta-adrenergic inotropic responses indicating a decrease in myocardial contractile reserve
• increase in basal contractility
• hypertrophy is associated with hypercontractility
• hypertrophy is associated with increased diastolic stiffness
• relative to wild-type mice and Nos3 single mutants
• identical to that in Nos3 single mutants

muscle
• develop age related concentric remodeling with marked increase in relative wall thickness
• increase in wall thickness and decrease in systolic and diastolic dimensions with age
• attenuation of the beta-adrenergic inotropic responses indicating a decrease in myocardial contractile reserve
• increase in basal contractility
• hypertrophy is associated with hypercontractility
• hypertrophy is associated with increased diastolic stiffness

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
hypertrophic cardiomyopathy DOID:11984 J:129064


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/05/2019
MGI 6.14
The Jackson Laboratory