Phenotypes Associated with This Genotype

Genotype
MGI:4367213

• Allelic Composition: Nos1^tm1Plh/Nos1^tm1Plh; Nos3^tm1Plh/Nos3^tm1Plh
• Genetic Background: B6.129S4-Nos3^tm1Plh Nos1^tm1Plh

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

heart left ventricle hypertrophy ( J:129064 )

• myocyte hypertrophy is detected by 4-5 months of age

• hypertrophy becomes more severe with age

cardiac interstitial fibrosis ( J:129064 )

• areas of focal interstitial fibrosis are seen in old (14-15 months of age) mice

increased cardiac muscle contractility ( J:129064 )

• prior to the development of frank left ventricular hypertrophy indices of myocardial contractility are elevated

• indices of contractility are also increased in old mice

• ejection fraction is increased in old mice

abnormal cardiac muscle relaxation ( J:129064 )

• passive diastolic relaxation appears impaired based on an increase in the time to peak filling

decreased left ventricle diastolic pressure ( J:129064 )

• decrease in left ventricular end diastolic pressure in young mice

increased heart rate ( J:129064 )

increased systemic arterial systolic blood pressure ( J:129064 )

• in young and old mice

muscle

heart left ventricle hypertrophy ( J:129064 )

• myocyte hypertrophy is detected by 4-5 months of age

• hypertrophy becomes more severe with age

increased cardiac muscle contractility ( J:129064 )

• prior to the development of frank left ventricular hypertrophy indices of myocardial contractility are elevated

• indices of contractility are also increased in old mice

• ejection fraction is increased in old mice

abnormal cardiac muscle relaxation ( J:129064 )

• passive diastolic relaxation appears impaired based on an increase in the time to peak filling

growth/size/body

heart left ventricle hypertrophy ( J:129064 )

• myocyte hypertrophy is detected by 4-5 months of age

• hypertrophy becomes more severe with age

cellular

cardiac interstitial fibrosis ( J:129064 )

• areas of focal interstitial fibrosis are seen in old (14-15 months of age) mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
hypertrophic cardiomyopathy		DOID:11984		J:129064