Phenotypes Associated with This Genotype

Genotype
MGI:4367198

• Allelic Composition: Aicda^tm1(cre)Mnz/Aicda⁺; Gt(ROSA)26Sor^{tm2(sb11)Njen}/Gt(ROSA)26Sor⁺; TgTn(sb-T2/Onc2)6070Njen/0
• Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:153656 )

• compared with Gt(ROSA)26Sor^{tm2(sb11)Njen} TgTn(sb-T2/Onc2)6070Njen mice

neoplasm

increased tumor incidence ( J:153656 )

• greater than 90% of moribund mice develop tumors with an average latency of 46 weeks

increased skin squamous cell carcinoma incidence ( J:153656 )

• in one mouse

increased medulloblastoma incidence ( J:153656 )

• in one mouse

increased hemolymphoid system tumor incidence ( J:153656 )

• mice develop hematopoietic tumors including B cell, T cell, and myeloid tumors unlike Gt(ROSA)26Sor^{tm2(sb11)Njen} TgTn(sb-T2/Onc2)6070Njen mice that do not develop tumors

increased T cell derived lymphoma incidence ( J:153656 )

• 3 T cell lymphomas develop

increased leukemia incidence ( J:153656 )

• 2 myeloid leukemia tumors develop

increased B cell derived lymphoma incidence ( J:153656 )

• mice develop B cell lymphomas including diffuse large cell lymphomas and follicular lymphomas

• one mouse developed pre-B lymphoma

increased follicular lymphoma incidence ( J:153656 )

integument

increased skin squamous cell carcinoma incidence ( J:153656 )

• in one mouse

nervous system

increased medulloblastoma incidence ( J:153656 )

• in one mouse

endocrine/exocrine glands

increased T cell derived lymphoma incidence ( J:153656 )

• 3 T cell lymphomas develop