Phenotypes Associated with This Genotype

Genotype
MGI:4366928

• Allelic Composition: Nos1^tm1Plh/Nos1^tm1Plh; Tg(SOD1)76Dpr/0
• Genetic Background: involves: 129S4/SvJae * C3H/HeJ * C57BL/6 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

decreased susceptibility to ischemic brain injury ( J:128835 )

• functional deficits following middle cerebral artery obstruction are reduced compared to wild-type controls but not compared to mice hemizygous for Tg(SOD1)76Dpr alone

decreased cerebral infarct size ( J:128835 )

• infarction sized induced by middle cerebral artery obstruction is reduced compared to wild-type controls

• however, the reduction in infarction size is not significantly different from that seen in mice hemizygous for Tg(SOD1)76Dpr alone

homeostasis/metabolism

decreased susceptibility to ischemic brain injury ( J:128835 )

• functional deficits following middle cerebral artery obstruction are reduced compared to wild-type controls but not compared to mice hemizygous for Tg(SOD1)76Dpr alone

decreased cerebral infarct size ( J:128835 )

• infarction sized induced by middle cerebral artery obstruction is reduced compared to wild-type controls

• however, the reduction in infarction size is not significantly different from that seen in mice hemizygous for Tg(SOD1)76Dpr alone