Phenotypes Associated with This Genotype

Genotype
MGI:4366921

• Allelic Composition: Mlh1^tm1Rak/Mlh1^tm1Rak
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:153684 )

• mice die before 15 months

neoplasm

increased intestinal adenocarcinoma incidence ( J:153684 )

• 42% of mice develop intestinal adenomas and adenocarcinomas compared with 5% of wild-type mice

increased intestinal adenoma incidence ( J:153684 )

• 42% of mice develop intestinal adenomas and adenocarcinomas compared with 5% of wild-type mice

increased lymphoma incidence ( J:153684 )

• 4% of mice develop nodal lymphomas and 31% of mice develop follicular lymphomas

increased T cell derived lymphoma incidence ( J:153684 )

• in 38% of mice unlike wild-type mice

endocrine/exocrine glands

increased T cell derived lymphoma incidence ( J:153684 )

• in 38% of mice unlike wild-type mice

digestive/alimentary system

increased intestinal adenocarcinoma incidence ( J:153684 )

• 42% of mice develop intestinal adenomas and adenocarcinomas compared with 5% of wild-type mice

increased intestinal adenoma incidence ( J:153684 )

• 42% of mice develop intestinal adenomas and adenocarcinomas compared with 5% of wild-type mice