Phenotypes Associated with This Genotype

Genotype
MGI:4366907

• Allelic Composition: Gigyf2^Gt(XH076)Byg/Gigyf2⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal neuron number ( J:153971 )

• at 15 months, mice exhibit a decrease in the neuronal to glial cell ratio compared to in wild-type mice

alpha-synuclein inclusion body ( J:153971 )

• mice exhibit an increase in alpha-synuclein+ neuritic plaques in the cerebrum and spinal cord compared to in wild-type mice

neurodegeneration ( J:153971 )

• in the spinal cord and brain

motor neuron degeneration ( J:153971 )

• at 15 months, mice exhibit eosinophilic degeneration with nuclear pyknosis, axonal swelling, and rare inclusion body-like structures predominantly in large pyramidal neurons in the ventral horns of the spinal cord unlike wild-type mice

behavior/neurological

abnormal motor capabilities/coordination/movement ( J:153971 )

• at 12 months, 50% of mice exhibit mild truncal and hind limb motor dysfunction with exaggerated splaying of the hind limbs and delayed positional correction when dropped 15 cm on a flat surface compared with wild-type mice

impaired coordination ( J:153971 )

• at 15 months, mice exhibit a 50% decrease in staying time on a rotarod compared with wild-type mice

cellular

abnormal cell cycle ( J:153971 )

• more mouse embryonic fibroblasts treated with etoposide are in S-phase than similarly treated wild-type cells