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Phenotypes Associated with This Genotype
Genotype
MGI:4366840
Allelic
Composition		 Bcl2tm1Dlo/Bcl2tm1Dlo
Bcl2l11tm1.1Boui/Bcl2l11tm2.1Boui
Genetic
Background		 B6.Cg-Bcl2tm1Dlo Bcl2l11tm1.1Boui/Bcl2l11tm2.1Boui
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl2l11tm1.1Boui mutation (0 available); any Bcl2l11 mutation (37 available)
Bcl2l11tm2.1Boui mutation (0 available); any Bcl2l11 mutation (37 available)
Bcl2tm1Dlo mutation (0 available); any Bcl2 mutation (40 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

BH3 replacement mutations in Bcl2l11 prevent the development of polycystic kidney disease and spleen atrophy in Bcl2tm1Dlo/Bcl2tm1Dlo mice

hematopoietic system
hematopoietic system phenotype ( J:153846 )
N
• normal splenic structure
increased spleen weight ( J:153846 )
• spleens are much heavier than those in homozygous Bcl-2 deficient mice
• spleens are much heavier than those in homozygous Bcl-2 deficient with only one Bcl2l1 deficient allele mice
increased leukocyte cell number ( J:153846 )
• white blood cells numbers are six fold more abundant than in homozygous Bcl-2 deficient mice

renal/urinary system
renal/urinary system phenotype ( J:153846 )
N
• mice do not develop polycystic kidney disease

immune system
immune system phenotype ( J:153846 )
N
• normal splenic structure
increased spleen weight ( J:153846 )
• spleens are much heavier than those in homozygous Bcl-2 deficient mice
• spleens are much heavier than those in homozygous Bcl-2 deficient with only one Bcl2l1 deficient allele mice
increased leukocyte cell number ( J:153846 )
• white blood cells numbers are six fold more abundant than in homozygous Bcl-2 deficient mice

growth/size/body
increased spleen weight ( J:153846 )
• spleens are much heavier than those in homozygous Bcl-2 deficient mice
• spleens are much heavier than those in homozygous Bcl-2 deficient with only one Bcl2l1 deficient allele mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory