Phenotypes Associated with This Genotype

Genotype
MGI:4366837

• Allelic Composition: Bcl2^tm1Dlo/Bcl2^tm1Dlo; Bcl2l11^tm3.1Boui/Bcl2l11^tm3.1Boui
• Genetic Background: B6.Cg-Bcl2^tm1Dlo Bcl2l11^tm3.1Boui

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

The Bcl2l11^tm3.1Boui mutation ameliorates the degenerative disorders of Bcl2^tm1Dlo/Bcl2^tm1Dlo mice

mortality/aging

premature death ( J:153846 )

• live up to 300 days due to mild polycystic kidney disease (PKD)

growth/size/body

polycystic kidney ( J:153846 )

• mild signs of polycystic kidney disease (PKD)

• progress slowly

• live up to 300 days

postnatal growth retardation ( J:153846 )

• retarded growth

• most of these animals (n = 24) become healthy adults

increased spleen weight ( J:153846 )

• spleens are heavier than those in homozygous Bcl-2 deficient mice

hematopoietic system

hematopoietic system phenotype ( J:153846 )

N • normal splenic structure

decreased splenocyte apoptosis ( J:153846 )

• less apoptosis than in homozygous Bcl-2 deficient mice spleen

increased spleen weight ( J:153846 )

• spleens are heavier than those in homozygous Bcl-2 deficient mice

increased leukocyte cell number ( J:153846 )

• more white blood cells numbers than in homozygous Bcl-2 deficient mice

renal/urinary system

polycystic kidney ( J:153846 )

• mild signs of polycystic kidney disease (PKD)

• progress slowly

• live up to 300 days

immune system

immune system phenotype ( J:153846 )

N • normal splenic structure

decreased splenocyte apoptosis ( J:153846 )

• less apoptosis than in homozygous Bcl-2 deficient mice spleen

increased spleen weight ( J:153846 )

• spleens are heavier than those in homozygous Bcl-2 deficient mice

increased leukocyte cell number ( J:153846 )

• more white blood cells numbers than in homozygous Bcl-2 deficient mice

cellular

decreased splenocyte apoptosis ( J:153846 )

• less apoptosis than in homozygous Bcl-2 deficient mice spleen