Phenotypes Associated with This Genotype

Genotype
MGI:4366836

• Allelic Composition: Bcl2^tm1Dlo/Bcl2^tm1Dlo; Bcl2l11^tm2.1Boui/Bcl2l11^tm2.1Boui
• Genetic Background: B6.Cg-Bcl2^tm1Dlo Bcl2l11^tm2.1Boui

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

BH3 replacement mutations in Bcl2l11 prevent the development of polycystic kidney disease and spleen atrophy in Bcl2^tm1Dlo/Bcl2^tm1Dlo mice

growth/size/body

growth/size/body region phenotype ( J:153846 )

N • grow normally

hematopoietic system

hematopoietic system phenotype ( J:153846 )

N • normal splenic structure

immune system

immune system phenotype ( J:153846 )

N • normal splenic structure

renal/urinary system

renal/urinary system phenotype ( J:153846 )

N • mice do not develop polycystic kidney disease diluted coat color [MP:0000371]

pigmentation

diluted coat color ( J:153846 )

• coat color becomes gray at 5 to 7 weeks of age

integument

diluted coat color ( J:153846 )

• coat color becomes gray at 5 to 7 weeks of age