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Phenotypes Associated with This Genotype
Genotype
MGI:4366836
Allelic
Composition		 Bcl2tm1Dlo/Bcl2tm1Dlo
Bcl2l11tm2.1Boui/Bcl2l11tm2.1Boui
Genetic
Background		 B6.Cg-Bcl2tm1Dlo Bcl2l11tm2.1Boui
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl2l11tm2.1Boui mutation (0 available); any Bcl2l11 mutation (32 available)
Bcl2tm1Dlo mutation (0 available); any Bcl2 mutation (41 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

BH3 replacement mutations in Bcl2l11 prevent the development of polycystic kidney disease and spleen atrophy in Bcl2tm1Dlo/Bcl2tm1Dlo mice

growth/size/body
growth/size/body region phenotype ( J:153846 )
N
• grow normally

hematopoietic system
hematopoietic system phenotype ( J:153846 )
N
• normal splenic structure

immune system
immune system phenotype ( J:153846 )
N
• normal splenic structure

renal/urinary system
renal/urinary system phenotype ( J:153846 )
N
• mice do not develop polycystic kidney disease diluted coat color [MP:0000371]

pigmentation
diluted coat color ( J:153846 )
• coat color becomes gray at 5 to 7 weeks of age

integument
diluted coat color ( J:153846 )
• coat color becomes gray at 5 to 7 weeks of age

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory