Phenotypes Associated with This Genotype

Genotype
MGI:4366766

• Allelic Composition: Pten^tm1.1Mwst/Pten^tm1.1Mwst; Tg(MMTVneu)202Mul/0; Tg(S100a4-cre)1Gle/0
• Genetic Background: involves: FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased mammary gland tumor incidence ( J:153747 )

• mesenchymal cells transplanted into wild-type mice induce more mammary tumors that similarly treated Pten^tm1.1Mwst/Pten^tm1.1Mwst Tg(MMTVneu)202Mul cells

• mammary tumors progress to adenoma, carcinoma in situ, and invasive carcinoma

increased mammary adenocarcinoma incidence ( J:153747 )

integument

increased mammary gland tumor incidence ( J:153747 )

• mesenchymal cells transplanted into wild-type mice induce more mammary tumors that similarly treated Pten^tm1.1Mwst/Pten^tm1.1Mwst Tg(MMTVneu)202Mul cells

• mammary tumors progress to adenoma, carcinoma in situ, and invasive carcinoma

increased mammary adenocarcinoma incidence ( J:153747 )

endocrine/exocrine glands

increased mammary gland tumor incidence ( J:153747 )

• mesenchymal cells transplanted into wild-type mice induce more mammary tumors that similarly treated Pten^tm1.1Mwst/Pten^tm1.1Mwst Tg(MMTVneu)202Mul cells

• mammary tumors progress to adenoma, carcinoma in situ, and invasive carcinoma

increased mammary adenocarcinoma incidence ( J:153747 )