Analysis Tools
adipose tissue
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• although mutants exhibit the average normal 15% body fat, they do not exhibit significant increases in percentage of body fat seen in 36% of the controls
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behavior/neurological
polyphagia
(
J:80053
)
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• when food intake is corrected for body weight, mutants are hyperphagic compared to controls
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cellular
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• muscle mitochondria have reduced ability to oxidize alpha-glycerophosphate
• the ratio between phosphocreatine and ATP at rest is decreased, indicating an increase in cytosolic ADP
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growth/size/body
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• 30% reduction in body weight after 5 weeks of age
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homeostasis/metabolism
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• reduction in urea concentration in males
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muscle
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• reduction in the fiber cross-sectional area of fiber types IIa and IIx/IIb in plantaris muscles and gastronecmius muscles
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• gastrocnemius and plantaris muscles show a fast to slow shift in fiber types promoting mainly IIa and IIx fibers at the expense of fastest and glycolytic type IIb fibers
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• decrease in the relative mass for the total leg
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• weight of fast twitch skeletal muscles (plantaris and gastrocnemius) are lower than in controls, whereas weights of slow twitch skeletal and heart muscle are unchanged
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limbs/digits/tail
