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Phenotypes Associated with This Genotype
Genotype
MGI:4366457
Allelic
Composition
Pax6tm2Pgr/Pax6tm2Pgr
Sox2tm1.1Lan/Sox2tm1.1Lan
Tg(Cryaa-cre)10Mlr/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pax6tm2Pgr mutation (1 available); any Pax6 mutation (93 available)
Sox2tm1.1Lan mutation (1 available); any Sox2 mutation (56 available)
Tg(Cryaa-cre)10Mlr mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• lens epithelial cells accumulate posterior to the lens equator unlike in wild-type mice
• anterior lens epithelium is reduced in size compared to in wild-type mice
• lens epithelial cells fail to exhibit the cell cycle

cellular


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/25/2025
MGI 6.24
The Jackson Laboratory