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Phenotypes Associated with This Genotype
Genotype
MGI:4366442
Allelic
Composition
Fmr1tm1Cgr/Y
Genetic
Background
involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fmr1tm1Cgr mutation (4 available); any Fmr1 mutation (22 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• the percentage of conditioned responses was reduced in the 2nd - 4th training sessions and peak amplitude and peak velocity were reduced in the 3rd and 4th training sessions
• in the reversal trials of the Morris water maze, mutants take more time to escape to the platform than controls
• in all eye blink conditioning training session the percentage and peak amplitudes of the startle responses were higher

endocrine/exocrine glands
• progressive enlargement resulting in testes that were 34% bigger than those of wild-type by 168-170 days of age
• macroorchidism decreases somewhat after 168-170 days of age

reproductive system
• progressive enlargement resulting in testes that were 34% bigger than those of wild-type by 168-170 days of age
• macroorchidism decreases somewhat after 168-170 days of age

nervous system
• the percentage of single climbing fiber innervation is increased, the length of spine heads and necks is increased, and spines are more irregular
• induction of long term depression in Purkinje cells is significantly enhanced when stimulating parallel fibers

Mouse Models of Human Disease
OMIM ID Ref(s)
Fragile X Mental Retardation Syndrome 300624 J:34449 , J:101021


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory