Mouse Genome Informatics
ot
    Fmr1tm1Cgr/Y
involves: 129P2/OlaHsd
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
behavior/neurological
• the percentage of conditioned responses was reduced in the 2nd - 4th training sessions and peak amplitude and peak velocity were reduced in the 3rd and 4th training sessions (J:101021)
• in the reversal trials of the Morris water maze, mutants take more time to escape to the platform than controls (J:34449)
• in all eye blink conditioning training session the percentage and peak amplitudes of the startle responses were higher (J:101021)

endocrine/exocrine glands
• progressive enlargement resulting in testes that were 34% bigger than those of wild-type by 168-170 days of age (J:34449)
• macroorchidism decreases somewhat after 168-170 days of age (J:34449)

reproductive system
• progressive enlargement resulting in testes that were 34% bigger than those of wild-type by 168-170 days of age (J:34449)
• macroorchidism decreases somewhat after 168-170 days of age (J:34449)

nervous system
• the percentage of single climbing fiber innervation is increased, the length of spine heads and necks is increased, and spines are more irregular (J:101021)
• induction of long term depression in Purkinje cells is significantly enhanced when stimulating parallel fibers (J:101021)

Mouse Models of Human Disease
OMIM IDRef(s)
Fragile X Mental Retardation Syndrome 300624 J:34449 , J:101021