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Phenotypes Associated with This Genotype
Genotype
MGI:4366045
Allelic
Composition
Cd209dtm1.1Cfg/Cd209dtm1.1Cfg
Genetic
Background
involves: C57BL/6 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd209dtm1.1Cfg mutation (1 available); any Cd209d mutation (25 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• 21 days post-infection with M. tuberculosis, mice exhibit lower TNF levels compared with similarly treated wild-type mice
• 21 days after infection with M. tuberculosis, lung bacterial counts are 5 to 31 times in similarly treated wild-type mice
• 21 days post-infection with M. tuberculosis, mice exhibit lower TNF levels compared with similarly treated wild-type mice
• 42 days after infection with M. tuberculosis, lung bacterial counts are 3 to 12 times in similarly treated wild-type mice
• however, M. tuberculosis infected mice exhibit normal bacterial colonization of the spleen, formation of granulomatous lesions, and mortality

homeostasis/metabolism
• 21 days post-infection with M. tuberculosis, mice exhibit lower TNF levels compared with similarly treated wild-type mice


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/25/2025
MGI 6.24
The Jackson Laboratory