Phenotypes Associated with This Genotype

Genotype
MGI:4366009

• Allelic Composition: Tcf3^tm4.1Cmu/Tcf3^tm4.1Cmu
• Genetic Background: involves: 129S/SvEv * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal immunoglobulin light chain V-J recombination ( J:153423 )

decreased pro-B cell number ( J:153423 )

• the B220+c-kit+ pro-B cells are severely reduced in the bone marrow compared to in wild-type mice

arrested B cell differentiation ( J:153423 )

• B cell development is partially blocked in fraction A and virtually no B cells are detected in the fraction C unlike in wild-type mice

absent B cells ( J:153423 )

• in the bone marrow and spleen

hematopoietic system

abnormal immunoglobulin light chain V-J recombination ( J:153423 )

decreased pro-B cell number ( J:153423 )

• the B220+c-kit+ pro-B cells are severely reduced in the bone marrow compared to in wild-type mice

arrested B cell differentiation ( J:153423 )

• B cell development is partially blocked in fraction A and virtually no B cells are detected in the fraction C unlike in wild-type mice

absent B cells ( J:153423 )

• in the bone marrow and spleen