Phenotypes Associated with This Genotype

Genotype
MGI:4365902

• Allelic Composition: Tg(tetO/CMV-Prnp*,-lacZ)33Mjy/0; Tg(Camk2a-rtTA)1237Kndl/0
• Genetic Background: involves: FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

increased aggression towards mice ( J:153494 )

• higher tendency to initiate fights with their littermates in both males and females

• reported when induced by removal of doxycycline from the diet starting from 6 week old

hyperresponsive to tactile stimuli ( J:153494 )

• reacts more violently to tail and toe pinch

• reported when induced by removal of doxycycline from the diet starting from 6 week old

limb grasping ( J:153494 )

• reported when induced by removal of doxycycline from the diet starting from 6 week old

• also reported when transgene expression is never suppressed

increased locomotor activity ( J:153494 )

• increased locomotor activity

• a small hypoactive group of individuals existed as well

• reported when induced by removal of doxycycline from the diet starting from 6 week old

circling ( J:153494 )

• stereotypical circling

• reported when induced by removal of doxycycline from the diet starting from 6 week old

• also reported when transgene expression is never suppressed

nervous system

astrocytosis ( J:153494 )

• in cortical and hippocampal regions

• reported when transgene expression is never suppressed

decreased brain weight ( J:153494 )

• significantly lighter brain weight with no difference in body weight

• reported when induced by removal of doxycycline from the diet starting from 6 week old

abnormal hippocampus morphology ( J:153494 )

• reported when transgene expression is never suppressed

• more condensed nuclei are observed in hippocampal neurons

• reduced neurofilament staining in the hippocampal regions

abnormal cerebral cortex morphology ( J:153494 )

• reported when transgene expression is never suppressed

• more condensed nuclei are observed in cortical neurons

• reduced neurofilament staining in the cortical regions

thin cerebral cortex ( J:153494 )

• thinner cortex

• reported when induced by removal of doxycycline from the diet starting from 6 week old

• also reported when transgene expression is never suppressed

neurodegeneration ( J:153494 )

• more condensed nuclei are observed in cortical and hippocampal neurons

• reduced neurofilament staining in the cortical and hippocampal regions

• reported when transgene expression is never suppressed

cellular

astrocytosis ( J:153494 )

• in cortical and hippocampal regions

• reported when transgene expression is never suppressed

abnormal plasma membrane morphology ( J:153494 )

• a portion of cyPrnP is membrane bound

• cyPrnP is associated with the hydrophobic lipid core of membranes

• cyPrnP forms ordered amyloid oligomer

• reported when transgene expression is never suppressed