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Phenotypes Associated with This Genotype
Genotype
MGI:4365717
Allelic
Composition
Tg(Vim*R113C)1Tmm/0
Genetic
Background
B6.CBA-Tg(Vim*R113C)1Tmm
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• aggregations lead to a posterior capsule rupture at the age of about 6 months, followed by protrusion of fiber cells into the posterior chamber
• the plasma membrane of fiber cells is highly disorganized with multiple invaginations
• large aggregates start around 6 weeks of age in lens fiber cells
• prominent aggregates from 12 weeks onwards
• aggregates are not terminal but transient structures that ultimately become degraded, with an increase in Hsp70 and a 30% increase in proteasome activity
• lenses are more fragile and display a disrupted fiber cell morphology
• turbid lenses and formation of posterior cataracts in adult mutant

cellular
• cytoplasmic protein inclusions formed that also contained endogenous protein
• transgenic protein is expressed appropriately in all mesenchymal cells

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
cataract 30 DOID:0110248 OMIM:116300
J:145782


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
12/03/2019
MGI 6.14
The Jackson Laboratory