Phenotypes Associated with This Genotype

Genotype
MGI:4365621

• Allelic Composition: Fbn1^Tsk/Fbn1^tm2Rmz
• Genetic Background: involves: 129S1/Sv * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal aorta elastin content ( J:63844 )

• in 3 week old mice fragmentation of elastic lamellae is seen in van-Gieson stained histological sections of the ascending aorta

integument

abnormal dermal layer morphology ( J:63844 )

abnormal dermis reticular layer morphology ( J:63844 )

• Trichrome-stained sections of skin of newborn show loose connective tissue contains excessive collagen fibers tightly bound to the muscle layer

abnormal dermis reticular layer collagen network ( J:63844 )

• Trichrome-stained sections of skin of newborn show loose connective tissue contains excessive collagen fibers tightly bound to the muscle layer