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Phenotypes Associated with This Genotype
Genotype
MGI:4365571
Allelic
Composition
Rnf128tm1.1Flv/Rnf128tm1.1Flv
Tg(TcraTcrb)425Cbn/0
Genetic
Background
involves: 129S6/SvEvTac * BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rnf128tm1.1Flv mutation (1 available); any Rnf128 mutation (10 available)
Tg(TcraTcrb)425Cbn mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• despite increasing antigen doses, CD4+ T cells cannot be tolerized unlike similarly treated wild-type cells and continue to exhibit increased T cell proliferation and IL2 production

homeostasis/metabolism

hematopoietic system

cellular


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/25/2025
MGI 6.24
The Jackson Laboratory