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Phenotypes Associated with This Genotype
Genotype
MGI:4365547
Allelic
Composition		 Ptpn11tm1.1Wbm/Ptpn11tm1.1Wbm
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptpn11tm1.1Wbm mutation (1 available); any Ptpn11 mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal Schwann cell physiology ( J:153219 )
• following treatment with His-TAT-NLS-cre, Schwann cells exhibit severely blunted Nrg1-induced proliferation and blocked Nrg1-induced migration compared with similarly treated wild-type cells even in the presence of the Shp2 inhibitor PHPS1

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory