Phenotypes Associated with This Genotype

Genotype
MGI:4365545

• Allelic Composition: Trim21^tm1Mwah/Trim21^tm1Mwah
• Genetic Background: C57BL/6-Trim21^tm1Mwah

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Tissue inflammation of ears of tagged Trim21^tm1MwahTrim21^tm1Mwah mice

mortality/aging

decreased survivor rate ( J:151775 )

• a slightly reduced (22% vs. 27%) Mendelian ratio homozygous mice were born

• time of death was not reported

hematopoietic system

enlarged spleen ( J:151775 )

• in mice with dermatitis

abnormal T cell activation ( J:151775 )

• splenic CD3+ T cells of homozygous mice had an increased frequency of T cells with an activated phenotype splenic CD3+ T cells of homozygous mice had an increased frequency of T cells with an activated phenotype splenic CD3+ T cells of homozygous mice had an increased frequency of T cells with an activated phenotype

• mice treated with Oxazolone showed accumulation of T cells with an activated phenotype

• there is no apparent immune phenotype or other physical abnormalities present in naive unmanipulated homozygous mice

immune system

enlarged spleen ( J:151775 )

• in mice with dermatitis

abnormal T cell activation ( J:151775 )

• splenic CD3+ T cells of homozygous mice had an increased frequency of T cells with an activated phenotype splenic CD3+ T cells of homozygous mice had an increased frequency of T cells with an activated phenotype splenic CD3+ T cells of homozygous mice had an increased frequency of T cells with an activated phenotype

• mice treated with Oxazolone showed accumulation of T cells with an activated phenotype

• there is no apparent immune phenotype or other physical abnormalities present in naive unmanipulated homozygous mice

abnormal interleukin level ( J:151775 )

• production of high amounts of the proinflammatory cytokines IL-6, IL-12/IL-23p40, TNF-alpha, and IL-17 and IL-23R expression after application of Oxazolone

abnormal tumor necrosis factor level ( J:151775 )

• production of high amounts of the proinflammatory cytokines IL-6, IL-12/IL-23p40, TNF-alpha, and IL-17 and IL-23R expression after application of Oxazolone

enlarged lymph nodes ( J:151775 )

• in mice with dermatitis

autoimmune response ( J:151775 )

• development of systemic autoimmunity

increased autoantibody level ( J:151775 )

• mice with dermatitis developed antinuclear antibodies (ANAs), with specificity for DNA, and autoantibodies to several lupus- associated autoantigens and other autoantigens

increased inflammatory response ( J:151775 )

• significantly higher contact hypersensitivity to low doses of the contact-sensitizing agent Oxazolone significantly higher contact hypersensitivity to low doses of the contact-sensitizing agent Oxazolone significantly higher contact hypersensitivity to low doses of the contact-sensitizing agent Oxazolone

dermatitis ( J:151775 )

• 25 wk after application of metal ear tags, >90% of homozygous mice had developed a very severe and progressive dermatitis emanating from the tagged ear, which did not occur in WT littermates

homeostasis/metabolism

abnormal interleukin level ( J:151775 )

• production of high amounts of the proinflammatory cytokines IL-6, IL-12/IL-23p40, TNF-alpha, and IL-17 and IL-23R expression after application of Oxazolone

abnormal tumor necrosis factor level ( J:151775 )

• production of high amounts of the proinflammatory cytokines IL-6, IL-12/IL-23p40, TNF-alpha, and IL-17 and IL-23R expression after application of Oxazolone

increased urine protein level ( J:151775 )

• kidney pathology with substantiated mesangium and intraglomerular immunoglobulin depositions, as well as proteinuria

renal/urinary system

increased urine protein level ( J:151775 )

• kidney pathology with substantiated mesangium and intraglomerular immunoglobulin depositions, as well as proteinuria

integument

dermatitis ( J:151775 )

• 25 wk after application of metal ear tags, >90% of homozygous mice had developed a very severe and progressive dermatitis emanating from the tagged ear, which did not occur in WT littermates

growth/size/body

enlarged spleen ( J:151775 )

• in mice with dermatitis