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Phenotypes Associated with This Genotype
Genotype
MGI:4365448
Allelic
Composition		 Themistm1Hasu/Themis+
Genetic
Background		 involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Themistm1Hasu mutation (0 available); any Themis mutation (55 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased CD4-positive, alpha-beta T cell number ( J:153235 )
• mice exhibit an intermediate decrease in thymic CD4+ cells compared to in wild-type mice and homozygotes
decreased CD8-positive, alpha-beta T cell number ( J:153235 )
• mice exhibit an intermediate decrease in thymic CD8+ cells compared to in wild-type mice and homozygotes

hematopoietic system
decreased CD4-positive, alpha-beta T cell number ( J:153235 )
• mice exhibit an intermediate decrease in thymic CD4+ cells compared to in wild-type mice and homozygotes
decreased CD8-positive, alpha-beta T cell number ( J:153235 )
• mice exhibit an intermediate decrease in thymic CD8+ cells compared to in wild-type mice and homozygotes

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory