Phenotypes Associated with This Genotype

Genotype
MGI:4365389

• Allelic Composition: Cdsn^tm1.1Ics/Cdsn^tm1.1Ics; Tg(KRT14-cre)1Ipc/0
• Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:153292 )

• die within 1 to 2 h of birth

homeostasis/metabolism

impaired skin barrier function ( J:153292 )

• impaired barrier function coincides with areas of skin detachment

• trans epidermal water loss increases dramatically after the onset of skin detachment

• dorsal skin grafted onto nude mice displays increased trans epidermal water loss

neoplasm

increased skin papilloma incidence ( J:153292 )

• papillomatosis is seen in dorsal skin grafted onto nude mice

integument

impaired skin barrier function ( J:153292 )

• impaired barrier function coincides with areas of skin detachment

• trans epidermal water loss increases dramatically after the onset of skin detachment

• dorsal skin grafted onto nude mice displays increased trans epidermal water loss

hairless ( J:153292 )

• dorsal skin grafted onto nude mice initially has sparse hairs that progressively disappear becoming totally absent by 9 weeks after grafting

mixed cellular infiltration to dermis ( J:153292 )

• seen in dorsal skin grafted onto nude mice

abnormal epidermal layer morphology ( J:153292 )

• blisters are seen between the stratum granulosum and stratum corneum

• in isolated sections of skin and in areas adjacent to zones of detachment at the transition from the stratum granulosum to the stratum corneum numerous split transitional desmosomes are seen

absent epidermis stratum corneum ( J:153292 )

• in zones of skin rupture

• however, the stratum corneum is present in areas with intact skin

hyperkeratosis ( J:153292 )

• seen in dorsal skin grafted onto nude mice

parakeratosis ( J:153292 )

• seen in dorsal skin grafted onto nude mice

epidermal hyperplasia ( J:153292 )

• prominent hyperplasia with papillomatosis is seen in dorsal skin grafted onto nude mice

spontaneous skin ulceration ( J:153292 )

• grafting of dorsal skin onto nude mice results in chronic ulceration of the grafted skin

abnormal skin condition ( J:153292 )

• severe skin detachment is seen in neonates

• when born by C-section mice appear normal until groomed by surrogate mothers after which skin detachment is rapidly apparent

• skin rupture starts in the ventral area, paws and snout and extends to the flanks

• dorsal skin grafted onto nude mice becomes hard and forms a scab that by 9 weeks post grafting completely replaces the epidermis

dermal cyst ( J:153292 )

• seen in dorsal skin grafted onto nude mice, characteristically result from degenerative hair follicles

increased skin papilloma incidence ( J:153292 )

• papillomatosis is seen in dorsal skin grafted onto nude mice

decreased skin tensile strength ( J:153292 )

• skin is extremely fragile and tears easily under mechanical stress

• tape stripping removes 3 times more protein compared to controls

growth/size/body

dermal cyst ( J:153292 )

• seen in dorsal skin grafted onto nude mice, characteristically result from degenerative hair follicles