Analysis Tools
hematopoietic system
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• bone marrow-derived dendritic cells form fewer podosomes with decreased turnover rates compared with wild-type cells
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• the proportion of mature marginal zone to marginal zone precursors and T2 cells is decreased compared to in wild-type mice
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• mice exhibit an increase in B220+ B cells in the spleen compared with wild-type mice
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• in the spleen
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• mice have fewer CD4+ CD3+ and CD8+ CD3+ T cells than in wild-type mice
• fewer CD3+ T cells, especially CD8+CD3+ and CD4+CD8+Cd3+ T cells, are observed in the spleen, lymph nodes, and thymus than in wild-type mice
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immune system
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• bone marrow-derived dendritic cells form fewer podosomes with decreased turnover rates compared with wild-type cells
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• the proportion of mature marginal zone to marginal zone precursors and T2 cells is decreased compared to in wild-type mice
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• mice exhibit an increase in B220+ B cells in the spleen compared with wild-type mice
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• in the spleen
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• mice have fewer CD4+ CD3+ and CD8+ CD3+ T cells than in wild-type mice
• fewer CD3+ T cells, especially CD8+CD3+ and CD4+CD8+Cd3+ T cells, are observed in the spleen, lymph nodes, and thymus than in wild-type mice
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• migration of dendritic cells is impaired compared to wild-type cells
• chemotaxis velocity of bone marrow-derived dendritic cells in response to CCL3 is decreased compared to similarly treated wild-type cells
• dendritic cells fail to exhibit an increase in phagocytosis of latex beads unlike similarly treated wild-type cells
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• at a low titer
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cellular
