Phenotypes Associated with This Genotype

Genotype
MGI:4362075

• Allelic Composition: Cebpb^tm1Aki/Cebpb^tm1Aki
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal T-helper 1 physiology ( J:153025 )

• using model of P. acnes infection in vivo, Th1 responses was reduced compared to wild type, similar to that of Cebpb deficient Cebpb^tim1Kish homozygous mice

abnormal macrophage physiology ( J:153025 )

• in vitro, LPS-stimulated mutant peritoneal macrophages exhibit impaired production of G-CSF and bioactive IL-12p70, whereas IL-12p40 is overproduced

decreased susceptibility to endotoxin shock ( J:153025 )

• using model of P. acnes infection in vivo, homozygous mutant mice are strongly resistant to LPS-induced endotoxin shock compared to wild type, similar to that of Cebpb deficient Cebpb^tim1Kish homozygous mice

granulomatous inflammation ( J:153025 )

• using model of P. acnes infection in vivo, granuloma formation was reduced compared to wild type, similar to that of Cebpb deficient Cebpb^tim1Kish homozygous mice

increased susceptibility to bacterial infection ( J:153025 )

• homozygous mice are susceptible to infection by Listeria monocytogenes in vivo compared to wild type, but milder than that of Cebpb deficient Cebpb^tim1Kish homozygous mice

• in vitro, LPS-stimulated mutant peritoneal macrophages exhibit no increased susceptibility to Listeria monocytogenes infection

hematopoietic system

abnormal T-helper 1 physiology ( J:153025 )

• using model of P. acnes infection in vivo, Th1 responses was reduced compared to wild type, similar to that of Cebpb deficient Cebpb^tim1Kish homozygous mice

abnormal macrophage physiology ( J:153025 )

• in vitro, LPS-stimulated mutant peritoneal macrophages exhibit impaired production of G-CSF and bioactive IL-12p70, whereas IL-12p40 is overproduced