Phenotypes Associated with This Genotype

Genotype
MGI:4362041

• Allelic Composition: Grin1^tm2Stl/Grin1^tm2Stl; Tg(Pomc-cre)1Lowl/0
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:122763 )

N • population responses recordings from the stimulated perforant path in the dentate hilus are not different from controls at 20-24 weeks

N • paired-pulse facilitation is normal

N • long term potentiation in area CA1 after Schaffer commissural input stimulation in CA3

N • hippocampal memory and discrimination is normal in mutants (measured by acquisition of contextual fear conditioning)

impaired synaptic plasticity ( J:122763 )

• theta-burst stimulation of the perforant path (PP) did not evoke potentiation (plasticity) of synapses of the PP-GC (dentate gyrus granule cells)

behavior/neurological

behavior/neurological phenotype ( J:122763 )

N • open field activity is not different from controls

N • no differences are seen in feeding behavior or body weights compared to controls

N • spatial learning in Morris water maze test is normal

abnormal discrimination learning ( J:122763 )

• mice show impaired acquisition of a discrimination task compared to controls; deficit is limited to early days of training, but is comparable to controls after extended training