Phenotypes Associated with This Genotype

Genotype
MGI:4361940

• Allelic Composition: Npy2r^tm1.1Hhz/Npy2r^tm1.1Hhz; Npy4r^tm1.1Hhz/Npy4r^tm1.1Hhz
• Genetic Background: involves: 129X1/SvJ * BALB/cJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

abnormal osteoblast physiology ( J:84570 )

• osteoblast bone formation is increased compared to in wild-type mice

abnormal bone structure ( J:84570 )

• periosteal diameter of the cortical shaft is reduced compared to in wild-type mice

decreased compact bone thickness ( J:84570 )

• cortical bone area and thickness are decreased compared to in wild-type mice

abnormal trabecular bone morphology ( J:84570 )

• mice exhibit an increase in cancellous bone volume, trabeculae number, and trabecular thickness compared with wild-type mice and single homozygotes

increased trabecular bone thickness ( J:84570 )

abnormal bone ossification ( J:84570 )

• mice exhibit increased bone turnover with osteoblast, osteoclast, and osteoid surfaces increased compared with wild-type mice and single homozygotes

• however, osteoblast and osteoclast numbers are normal

abnormal bone mineralization ( J:84570 )

• mineral apposition rate is increased compared to in wild-type mice

homeostasis/metabolism

decreased circulating insulin level ( J:84570 )

♂ • in male mice compared with wild-type mice

decreased circulating leptin level ( J:84570 )

♂ • in male mice compared with wild-type mice and Ppyr1^tm1.1Hhz homozygotes

increased circulating pancreatic peptide level ( J:84570 )

• plasma pancreatic peptide levels are increased compared to in wild-type mice

adipose tissue

decreased brown adipose tissue amount ( J:84570 )

decreased white adipose tissue amount ( J:84570 )

♂ • male mice exhibit a decreased in white adipose tissue compared to in wild-type mice or single homozygotes

growth/size/body

decreased body weight ( J:84570 )

♂ • male mice exhibit decreased body weight compared with wild-type mice that is not as severe as in single homozygotes

behavior/neurological

abnormal eating behavior ( J:84570 )

♂ • in male mice compared to in wild-type mice and single homozygotes

cellular

abnormal osteoblast physiology ( J:84570 )

• osteoblast bone formation is increased compared to in wild-type mice