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Phenotypes Associated with This Genotype
Genotype
MGI:4361923
Allelic
Composition		 Shc1tm9Paw/Shc1tm9Paw
Tg(MMTV-Erbb2*,-cre)1Mul/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Shc1tm9Paw mutation (0 available); any Shc1 mutation (66 available)
Tg(MMTV-Erbb2*,-cre)1Mul mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
neoplasm ( J:133325 )
N
• mammary tumor development is completely ablated

reproductive system
reproductive system phenotype ( J:133325 )
N
• mammary glands show no hyperplastic or neoplastic lesions within mammary epithelial cells mammary glands show no hyperplastic or neoplastic lesions within mammary epithelial cells

endocrine/exocrine glands
abnormal mammary gland morphology ( J:133325 )
• compared to wild-type FVB controls, proliferative index of mammary epithelial cells is strongly reduced and apoptotic index is significantly increased

integument
abnormal mammary gland morphology ( J:133325 )
• compared to wild-type FVB controls, proliferative index of mammary epithelial cells is strongly reduced and apoptotic index is significantly increased

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/20/2026
MGI 6.24 		The Jackson Laboratory