Phenotypes Associated with This Genotype

Genotype
MGI:4361880

• Allelic Composition: Dab1^scm-4J/Dab1^scm-4J
• Genetic Background: CBA/J-Dab1^scm-4J/GrsrJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:153275 )

• although most homozygotes live to adulthood, some die by three weeks of age

growth/size/body

decreased body size ( J:153275 )

• evident at 2 weeks of age

behavior/neurological

tremors ( J:153275 )

abnormal gait ( J:153275 )

• leaning side-to-side gait

hematopoietic system

thymus atrophy ( J:153275 )

immune system

thymus atrophy ( J:153275 )

nervous system

abnormal brain morphology ( J:153275 )

• scrambled neurons in the brain

skeleton

abnormal bone marrow morphology ( J:153275 )

• homozygotes are described as having poor marrow

endocrine/exocrine glands

thymus atrophy ( J:153275 )