Phenotypes Associated with This Genotype

Genotype
MGI:4361628

• Allelic Composition: Mt1^tm1Bri/Mt1^tm1Bri; Mt2^tm1Bri/Mt2^tm1Bri
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased physiological sensitivity to xenobiotic ( J:116275 )

• NMDA-treated mice exhibit reduced cells in the retinal ganglion cell layer compared with similarly treated wild-type mice

• mice fail to exhibit protective effect of ZnSO4 against NMDA-induced retinal ganglion cell layer damage unlike similarly treated wild-type mice

• however, inner plexiform layer thickness following treatment with NMDA is normal

vision/eye

abnormal retina ganglion layer morphology ( J:116275 )

• NMDA-treated mice exhibit reduced cells in the retinal ganglion cell layer compared with similarly treated wild-type mice