Phenotypes Associated with This Genotype

Genotype
MGI:4361588

• Allelic Composition: Abl1^tm1Mlg/Abl1^tm1Mlg; Tg(ACTB-Abl1*K290R)1Spg/0
• Genetic Background: involves: 129S/SvEv * C57BL/6J * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased survivor rate ( J:34643 )

• very low numbers reach weaning age; mortality among survivors continues after weaning with all (6/6) survivors dying within 3-6 months

postnatal lethality, incomplete penetrance ( J:34643 )

• low numbers of homozygotes are detected at weaning

digestive/alimentary system

abnormal digestive system morphology ( J:34643 )

• animals exhibit bloated gastrointestinal tracts at time of death

hematopoietic system

abnormal spleen morphology ( J:34643 )

• abnormal shape is observed with high prevalence in survivors

immune system

abnormal spleen morphology ( J:34643 )

• abnormal shape is observed with high prevalence in survivors

increased susceptibility to infection ( J:34643 )

• survivors often succumb to infections