Phenotypes for Atp7a Mt1 Mt2 MGI:4361578 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Atp7a^Mo-brJ/Atp7a⁺ Mt1^tm1Bri/Mt1^tm1Bri Mt2^tm1Bri/Mt2^tm1Bri
Genetic Background	involves: 129S7/SvEvBrd * C3H/HeJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atp7a^Mo-brJ mutation (0 available); any Atp7a mutation (67 available)
Mt1^tm1Bri mutation (1 available); any Mt1 mutation (48 available)
Mt2^tm1Bri mutation (1 available); any Mt2 mutation (14 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:33276 )

• no mice are recovered at E11

cellular

increased sensitivity to induced cell death ( J:33276 )

• cells from E11 embryos exhibit increased cell death when cultured with copper compared with similarly treated heterozygous cells

growth/size/body

decreased body size ( J:33276 )

• the one surviving mouse was runted

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:33276 )

N	• the one recovered mouse had normal copper levels in the intestine and liver

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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