Phenotypes Associated with This Genotype

Genotype
MGI:4361558

• Allelic Composition: Nrcam²⁰⁸⁸⁴/Nrcam²⁰⁸⁸⁴
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

decreased grip strength ( J:153042 )

• inconsistently significant weakness is detected in the forepaws starting a 14 weeks of age

• however, hindpaw grip strength is normal

nervous system

nervous system phenotype ( J:153042 )

N • unlike Nrcam²⁰⁸⁸⁴ Lpin1²⁰⁸⁸⁴ double homozygotes no defects in nerve morphology are detected

decreased nerve conduction velocity ( J:153042 )

• by 8 weeks of age conduction velocity is reduced in the sciatic nerve and the sural nerve

• decrease is less than in Nrcam²⁰⁸⁸⁴ Lpin1²⁰⁸⁸⁴ double homozygotes

• by 12 weeks of age nerve conduction in the sciatic nerve but not the sural nerve is similar to wild-type controls