Analysis Tools
digestive/alimentary system
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• at E18.5, all mice exhibit anorectal malformations and fail to show continuity of the rectum and anal epithelium unlike in wild-type mice
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absent anus
(
J:153152
)
anal atresia
(
J:153152
)
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• at E18.5
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• at E15.5, mice exhibit a fistula between the bladder and the colon unlike wild-type mice
• at E18.5, only 25% of mice display a fistula between the bladder and colon unlike in wild-type mice
• most mice exhibit a blind-ending pouch without a fistula unlike in wild-type mice
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• mice exhibit a shortening of the colon
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• at E18.5, all mice exhibit anorectal malformations and fail to show continuity of the rectum and anal epithelium unlike in wild-type mice
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• mice lack rectal tissues
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renal/urinary system
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• at E15.5, mice exhibit a fistula between the bladder and the colon unlike wild-type mice
• at E18.5, only 25% of mice display a fistula between the bladder and colon unlike in wild-type mice
• most mice exhibit a blind-ending pouch without a fistula unlike in wild-type mice
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liver/biliary system
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• the liver is displaced caudally
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limbs/digits/tail
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• truncated
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short tail
(
J:153152
)
reproductive system
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• at E10.5, E11.5 and E12.5
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• increase in apoptosis of extragonadal primordial germ cells at E10.5 and E11.5
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• fail to migrate rostrally at E10.5, remaining caudally distributed
• ectopic PGCs make up over 70% of the total PGCs at E11.5 compared to less than 5% in wild-type controls
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• at E18.5, the genital tubercle is hypoplastic compared to in wild-type mice
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growth/size/body
nervous system
| N |
• mice exhibit normal numbers of thoracic motor neurons and proportions of motor columnar subtypes
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cellular
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• at E10.5, E11.5 and E12.5
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• increase in apoptosis of extragonadal primordial germ cells at E10.5 and E11.5
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• fail to migrate rostrally at E10.5, remaining caudally distributed
• ectopic PGCs make up over 70% of the total PGCs at E11.5 compared to less than 5% in wild-type controls
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