Mouse Genome Informatics
hm
    Wnt5atm1Amc/Wnt5atm1Amc
involves: 129S7/SvEvBrd
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       

Primordial germ cell depletion in Ror2Y324C/Ror2Y324C and Wnt5atm1Amc/Wnt5atm1Amc mice

digestive/alimentary system
• at E18.5, all mice exhibit anorectal malformations and fail to show continuity of the rectum and anal epithelium unlike in wild-type mice
• at E18.5
• at E15.5, mice exhibit a fistula between the bladder and the colon unlike wild-type mice
• at E18.5, only 25% of mice display a fistula between the bladder and colon unlike in wild-type mice
• most mice exhibit a blind-ending pouch without a fistula unlike in wild-type mice
• mice exhibit a shortening of the colon
• at E18.5, all mice exhibit anorectal malformations and fail to show continuity of the rectum and anal epithelium unlike in wild-type mice
• mice lack rectal tissues

renal/urinary system
• at E15.5, mice exhibit a fistula between the bladder and the colon unlike wild-type mice
• at E18.5, only 25% of mice display a fistula between the bladder and colon unlike in wild-type mice
• most mice exhibit a blind-ending pouch without a fistula unlike in wild-type mice

liver/biliary system
• the liver is displaced caudally

limbs/digits/tail

reproductive system
• increase in apoptosis of extragonadal primordial germ cells at E10.5 and E11.5
• fail to migrate rostrally at E10.5, remaining caudally distributed
• ectopic PGCs make up over 70% of the total PGCs at E11.5 compared to less than 5% in wild-type controls
• at E10.5, E11.5 and E12.5
• at E18.5, the genital tubercle is hypoplastic compared to in wild-type mice

growth/size

nervous system
N
• mice exhibit normal numbers of thoracic motor neurons and proportions of motor columnar subtypes (J:155074)

cellular
• increase in apoptosis of extragonadal primordial germ cells at E10.5 and E11.5
• fail to migrate rostrally at E10.5, remaining caudally distributed
• ectopic PGCs make up over 70% of the total PGCs at E11.5 compared to less than 5% in wild-type controls

Mouse Models of Human Disease
OMIM IDRef(s)
Anorectal Anomalies 107100 J:153152