Phenotypes for Del(17)T<hp> Map3k4 MGI:4361425 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Del(17)T^hp/Map3k4^byg
Genetic Background	involves: AKR/J * C3H/HeH * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Del(17)T^hp mutation (3 available); any Del(17)T^hp mutation (2 available)
Map3k4^byg mutation (1 available); any Map3k4 mutation (79 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

XY embryos doubly heterozygous for Map3k4^byg and Del(17)T^hp exhibit a range of defects of gonad development similar to Map3k4^byg homozygotes

reproductive system

abnormal testis cord formation ( J:153050 )

• testes exhibit regions lacking clear cord morphology unlike in wild-type mice

primary sex reversal ( J:153050 )

• at E13.5 and E14.5, XY gonads exhibit disruption in cord morphology or gonadal sex reversal

nervous system

abnormal neural tube morphology ( J:153050 )

endocrine/exocrine glands

abnormal testis cord formation ( J:153050 )

• testes exhibit regions lacking clear cord morphology unlike in wild-type mice

embryo

abnormal neural tube morphology ( J:153050 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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